New research suggests that people who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end traditional diet and exercise regimens.
Research printed in a prominent medical journal demonstrates that while overweight people frequently drop a large proportion of their body weight while undergoing treatment, the weight comes back at an average rate of 0.8 kg per month after stopping.
"Individuals purchasing these treatments must be aware of the danger of rapid rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
That rate of regain implies a return to pre-treatment mass within about 18 months.
Weighing Approaches
The analysis, which looked at 37 of studies involving over 9,000 of participants, compared the results of the injectable medications with other pills.
Scientists note that people who shed pounds through diet and exercise typically experience a less rapid weight regain—approximately 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Experts propose the mechanism of the drugs accounts for the amplified rebound.
GLP-1 drugs copy a natural hormone called GLP-1, which controls hunger.
"Artificially providing the hormone concentrations several times higher than the body's typical production might result in the body to generate a reduced amount of its own natural GLP-1, and may also reduce responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this GLP-1 'fix' means appetite is uncontrolled, making overeating much more probable."
A Chronic Condition?
Medical guidelines recommend the injections for individuals with obesity-related health risks, alongside prescribed diet and exercise modifications.
Many experts contend that, considering the significant potential of weight regain, the therapy should be considered long-term.
This opinion is echoed by pharmaceutical companies, who state that the results "highlight the long-term character of excess weight," akin to managing diseases like hypertension.
Patient Experiences
Users who have discontinued the medication describe a intense return of hunger.
"It was like a switch that goes on and you're instantly starving," recalled an individual.
This difficulty is worsened if users have not established permanent lifestyle or habit changes during treatment.
Widespread Adoption
Survey data show that millions of people in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Adoption is greater among females than males.
- The 40s and 50s age group shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
Finally, researchers caution that while GLP-1 drugs are effective agents for shedding pounds, they are not a magic solution and lasting health benefits relies on integrated lifestyle support.
